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CME

PARP Combination Therapies: A New Horizon in Prostate Cancer Care

Multimedia
In this on-demand webcast of a live symposium, expert faculty discuss optimal use of PARP inhibitors in the clinic, guidance on genetic testing to select patients for this therapy, and the latest evidence on PARP inhibitor combinations to expand their benefit.

Physicians: Maximum of 1.50 AMA PRA Category 1 Credits

Released: March 30, 2022

Expiration: March 29, 2023

No longer available for credit.

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Faculty

Wassim Abida

Wassim Abida, MD, PhD

Director of Translational Research, Prostate Cancer
Associate Member
Genitourinary Oncology Service
Memorial Sloan Kettering Cancer Center
Associate Professor of Medicine
Weill Cornell Medical College
New York, New York

Heather H. Cheng

Heather H. Cheng, MD, PhD

Associate Professor
Department of Medicine (Hematology and Oncology)
University of Washington
Division of Clinical Research
Fred Hutchinson Cancer Center
Seattle, Washington

Maha Hussain

Maha Hussain, MD, FACP, FASCO

Genevieve Teuton Professor of Medicine
Division of Hematology/Oncology
Deputy Director
Robert H. Lurie Comprehensive Cancer Center
Northwestern University Feinberg School of Medicine
Chicago, Illinois

Provided by

Provided by Clinical Care Options, LLC
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Supporters

Supported by educational grants from

AstraZeneca

Merck Sharp & Dohme Corp.

Pfizer, Inc.

Target Audience

This program is intended for oncologists and other healthcare professionals who care for patients with prostate cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:
  • Select patients for treatment with currently approved PARP inhibitors by assessing DDR alterations
  • Effectively communicate to colleagues and patients the rationale for PARP inhibitor–based combinations in prostate cancer, in tumors with or without DDR alterations
  • Delineate the change in treatment sequence if phase III studies testing PARP inhibitor–based combinations for prostate cancer are positive
  • Manage adverse events associated with the use of PARP inhibitor combinations
  • Identify patients suitable for enrollment on ongoing clinical studies investigating PARP inhibitor combinations in prostate cancer

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Program Director Disclosure

Program Director

Maha Hussain, MD, FACP, FASCO

Genevieve Teuton Professor of Medicine
Division of Hematology/Oncology
Deputy Director
Robert H. Lurie Comprehensive Cancer Center
Northwestern University Feinberg School of Medicine
Chicago, Illinois

Maha Hussain, MD, FACP, FASCO, has disclosed that she has received consulting fees from AstraZeneca, Bayer, Bristol-Myers Squibb, Janssen, Merck, Novartis, Pfizer, and Tempus and funds for research support paid to her institution from Arvinas, AstraZeneca, Bayer, and Genentech.

Faculty Disclosure

Primary Author

Wassim Abida, MD, PhD

Director of Translational Research, Prostate Cancer
Associate Member
Genitourinary Oncology Service
Memorial Sloan Kettering Cancer Center
Associate Professor of Medicine
Weill Cornell Medical College
New York, New York

Wassim Abida, MD, PhD, has disclosed that he has received consulting fees from AstraZeneca/MedImmune, Clovis Oncology, Daiichi Sankyo, Janssen, ORIC, and Roche and funds for research support paid to his institution from AstraZeneca, Clovis Oncology, Epizyme, ORIC, and Zenith Epigenetics.

Heather H. Cheng, MD, PhD

Associate Professor
Department of Medicine (Hematology and Oncology)
University of Washington
Division of Clinical Research
Fred Hutchinson Cancer Center
Seattle, Washington

Heather H. Cheng, MD, PhD, has disclosed that she has received consulting fees from AstraZeneca and funds for research support from Astellas, Clovis, Color Genomics, Janssen, Medivation, Phosplatin, and Sanofi.

Staff Disclosure

Staff

Rachael M. Andrie, PhD

Clinical Editor

Rachael M. Andrie, PhD, has no relevant conflicts of interest to report.

Gordon Kelley,

Clinical Editor
Clinical Care Options, LLC

Gordon Kelley has no relevant conflicts of interest to report.

Lisa Kuhns, PhD

Lisa Kuhns, PhD, has no relevant conflicts of interest to report.

Jim Mortimer,

Product Director, Hematology/Oncology
Clinical Care Options, LLC

Jim Mortimer has disclosed that he had individual publicly traded stocks and stock options with AstraZeneca.

Kevin Obholz, PhD

Editorial Director, Hematology/Oncology

Kevin Obholz, PhD, has no relevant conflicts of interest to report.

Shara Pantry, PhD

Associate Scientific Director

Shara Pantry, PhD, has no relevant conflicts of interest to report.

Timothy A. Quill, PhD

Senior Managing Editor

Timothy A. Quill, PhD, has no relevant conflicts of interest to report.

June Wasserstrom,

Director, CME Program Development

June Wasserstrom has no relevant conflicts of interest to report.

Instructions for Credit

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Credit Designation

CCO designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Additional Information

Participation in this self-study activity should be completed in approximately 1.5 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from March 30, 2022, through March 29, 2023:

1. Register online at http://www.clinicaloptions.com.
2. Read the target audience, learning objectives, and faculty disclosures.
3. Study the educational activity online or printed out.
4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65% and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the posttest confirmation page. Records of all CME/CE activities completed can be found on the "CME/CE Manager" page. There are no costs/fees for this activity.

Program Medium

This program has been made available online.


Goal


The goal of this activity is to improve the knowledge, confidence, and competence of learners to understand PARP inhibitor combination mechanisms and rationale and to integrate recent findings into the management of men with prostate cancer.