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CME

Advances in CAR T-Cell Therapy for Leukemia, Lymphoma, and Myeloma: Where We Are and Where We Are Going

Case Challenge
Multimedia
In this interactive, CME-certified Webcast, experts review the latest updates in CAR-T cell therapy and offer their insights on current best practices for patients with hematologic cancers.

Physicians: Maximum of 2.25 AMA PRA Category 1 Credits

Released: January 30, 2020

Expiration: January 29, 2021

No longer available for credit.

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Faculty

Matthew J. Frigault

Matthew J. Frigault, MD

Instructor of Medicine
Division of Oncology
Department of Internal Medicine
Harvard Medical School
Clinical Assistant
Hematopoietic Cell Transplant and Cellular Therapy Program
Massachusetts General Hospital Cancer Center
Boston, Massachusetts

James K. Kochenderfer

James K. Kochenderfer, MD

Investigator, Security Branch
National Cancer Institute
Bethesda, Maryland

Jae H. Park

Jae H. Park, MD

Associate Member
Leukemia Service and Cellular Therapeutics Center
Memorial Sloan Kettering Cancer Center
New York, New York

Stephen J. Schuster

Stephen J. Schuster, MD

Robert and Margarita Louis-Dreyfus Professor of CLL and Lymphoma
Division of Hematology/Oncology
Department of Medicine
University of Pennsylvania
Director, Lymphoma Program and Lymphoma Translational Research
Abramson Cancer Center
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania

Provided by

Provided by Clinical Care Options, LLC
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Supporters

Supported by an educational grant from

Celgene

Kite A GILEAD Company

Target Audience

This activity is intended for physicians and other healthcare providers who treat and manage patients with leukemia, lymphoma, or myeloma who are candidates for CAR T-cell therapies.

Learning Objectives

Upon completion of this activity, participants should be able to:
  • Review the biologic principles underlying CAR T-cell therapy, structure and function of the CAR, and the mechanism of action of CAR T-cell
  • Identify characteristics of patients that are appropriate for treatment with CAR T-cell therapy
  • Review the clinical trial data of CAR T-cell–based therapies for the treatment of leukemia and lymphoma patients, and describe where CAR T-cell therapies might fit into the treatment landscape
  • Evaluate emerging clinical data and novel approaches to CAR T-cell therapy for patients with myeloma
  • Based on the current best evidence, implement strategies for managing toxicities associated with CAR T-cell therapy
  • Recall ongoing clinical trials evaluating CAR T-cell therapy for the treatment of leukemia, lymphoma, and myeloma to aid referral of appropriate patients

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any relevant conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:

Program Director Disclosure

Program Director

Stephen J. Schuster, MD

Robert and Margarita Louis-Dreyfus Professor of CLL and Lymphoma
Division of Hematology/Oncology
Department of Medicine
University of Pennsylvania
Director, Lymphoma Program and Lymphoma Translational Research
Abramson Cancer Center
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania

Stephen J. Schuster, MD, has disclosed that he has received consulting fees from AbbVie, Aptitude Health, Celgene, Juno, Loxo Oncology, Nordic Nanovector, Novartis, and Tessa Therapeutics; funds for research support from AbbVie, Celgene, Genentech, Juno, Loxo Oncology, Merck, and Novartis; and owns intellectual property rights with Novartis.

Faculty Disclosure

Primary Author

Matthew J. Frigault, MD

Instructor of Medicine
Division of Oncology
Department of Internal Medicine
Harvard Medical School
Clinical Assistant
Hematopoietic Cell Transplant and Cellular Therapy Program
Massachusetts General Hospital Cancer Center
Boston, Massachusetts

Matthew J. Frigault, MD, has disclosed that he has received consulting fees from Arcellx, Celgene, Foundation, Kite/Gilead Sciences, Nkarta, Novartis, and Xenetic.

James K. Kochenderfer, MD

Investigator, Security Branch
National Cancer Institute
Bethesda, Maryland

James K. Kochenderfer, MD, has disclosed that he has received funds for research support from Celegene and Kite Pharma, and royalty fees from bluebird bio.

Jae H. Park, MD

Associate Member
Leukemia Service and Cellular Therapeutics Center
Memorial Sloan Kettering Cancer Center
New York, New York

Jae Park, MD, has disclosed that he has received consulting fees from Amgen, Allogene, AstraZeneca, Autolus, GlaxoSmithKline, Kite Pharma, Novartis, and Takeda.

Staff Disclosure

Staff

Kiran Mir-Hudgeons, PhD

Clinical Editor

Kiran Mir-Hudgeons, PhD, has no relevant conflicts of interest to report.

Kevin Obholz, PhD

Editorial Director, Hematology/Oncology

Kevin Obholz, PhD, has no relevant conflicts of interest to report.

Anna Poppa,

Managing Editor, HIV
Clinical Care Options, LLC

Anna Poppa has no relevant conflicts of interest to report.

Timothy A. Quill, PhD

Senior Managing Editor

Timothy Quill, PhD, has no relevant conflicts of interest to report.

Tina B. Stacy, PharmD, FACEHP, BCOP, CHCP

Executive Vice President, Educational Strategy
General Manager, Oncology

Tina B. Stacy, PharmD, FACEHP, BCOP, CHCP, has no relevant conflicts of interest to report.

Ryan P. Topping, PhD

Associate Managing Editor

Ryan Topping, PhD, has no relevant conflicts of interest to report.

June Wasserstrom,

Director, CME Program Development

June Wasserstrom has no relevant conflicts of interest to report.

Instructions for Credit

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Credit Designation

CCO designates this enduring material for a maximum of 2.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Additional Information

Participation in this self-study activity should be completed in approximately 2.25 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from January 30, 2020, through January 29, 2021:

1. Register online at http://www.clinicaloptions.com.
2. Read the target audience, learning objectives, and faculty disclosures.
3. Study the educational activity online or printed out.
4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65% and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the posttest confirmation page. Records of all CME/CE activities completed can be found on the "CME/CE Manager" page. There are no costs/fees for this activity.

Program Medium

This program has been made available online.


Goal


The goal of this activity is to improve participants’ knowledge of and competence in integrating CAR T-cell therapy into the treatment of patients with leukemia, lymphoma, and myeloma.