<i>NTRK</i> Testing Rationale
Rationale for NTRK Testing in Patients With Cancer

Released: October 08, 2021

Expiration: October 07, 2022

George D. Demetri
George D. Demetri, MD
Alexander E Drilon
Alexander E Drilon, MD

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In this episode, George D. Demetri, MD, and Alexander Drilon, MD, discuss the biologic rationale behind testing for NTRK fusions in patients with various solid tumors, along with clinical strategies for testing. Topics include:

  • Differences between NTRK fusions vs gene mutations
  • Frequency of NTRK fusions by age and tumor type
  • When to test patients for NTRK fusions and interpreting reports
  • Methods of testing: multiplex gene testing, next-generation sequencing of DNA vs RNA, immunohistochemistry, and liquid biopsy