eCase - Melanoma Think Tank

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Think Tank on Melanoma: Optimizing Therapy for Patients in an Evolving Treatment Landscape

Evan J. Lipson, MD

Activity

Introduction

For those providing patient care, how many patients with melanoma do you provide care for in a typical month?

In your current practice, what therapy would you recommend for an otherwise healthy asymptomatic 58-year-old patient with newly diagnosed stage IV BRAF^V600E-mutant melanoma with no brain metastases and the goal of maximizing progression-free survival (PFS)?

For a patient receiving nivolumab plus ipilimumab for stage IV melanoma who develops grade 2 diarrhea, in addition to close monitoring, which of the following proactive strategies would you use to manage this adverse event and decrease the possibility of worsening?

For a patient with resected stage IIIC BRAF wild-type melanoma, which of the following FDA-approved therapies would you recommend in the adjuvant setting?

Lifileucel is a tumor-infiltrating lymphocyte (TIL) therapy that was examined in a phase II trial of patients with previously treated advanced melanoma refractory to anti‒PD-1 therapy. Which of the following statements accurately represents the efficacy findings from this trial?