ART Management When HTE

CE / CME

Foundations of ART Management in Heavily Treatment–Experienced Patients

Pharmacists: 1.00 contact hour (0.1 CEUs)

Physicians: Maximum of 1.00 AMA PRA Category 1 Credit

Released: October 06, 2022

Expiration: October 05, 2023

Eric S. Daar
Eric S. Daar, MD

Activity

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We will now investigate different situations in which we treat people who have underlying drug-resistant virus. The first situation includes those with first-line or second-line treatment failures. These data provide some guidance on how to treat those who are even more experienced.

These are data describing samples submitted to Monogram Biosciences for resistance testing.They describe the trends in drug resistance in the United States. The figure illustrates the proportion with 1-class, 2-class, 3-class, or 4-class resistance.

As we might have predicted, the greatest proportion have 1-class resistance; a smaller proportion have 2-class resistance; and the 3-class– and 4-class–resistant populations are much rarer.

Note that the trends are either flat or declining in all cases except 1-class resistance. This is consistent with the fact that, in recent years, we have better regimens—often with high barriers to resistance—so that resistant virus is less frequently selected.