Expert Analysis

CME

Key Studies in Myeloma: CCO Independent Conference Highlights of the 2020 Virtual ASH Annual Meeting

Physicians: Maximum of 1.50 AMA PRA Category 1 Credits

Released: March 22, 2021

Expiration: March 21, 2022

Shaji K. Kumar
Shaji K. Kumar, MD
Sagar Lonial
Sagar Lonial, MD, FACP

Activity

Progress
1
Course Completed

References

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  23. US Food and Drug Administration. FDA approves daratumumab and hyaluronidase-fijh for multiple myeloma. Available at: https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-daratumumab-and-hyaluronidase-fihj-multiple-myeloma. Accessed March 5, 2021.
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  25. ClinicalTrials.gov. Comparison of pomalidomide and dexamethasone with or without daratumumab in subjects with relapsed or refractory multiple myeloma previously treated with lenalidomide and a proteasome inhibitor/daratumumab/pomalidomide/dexamethasone vs pomalidomide/dexamethasone (EMN14). Available at: https://clinicaltrials.gov/ct2/show/NCT03180736. Accessed March 5, 2021.
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  31. Argueta C, Kashyap T, Klebanov B, et al. Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death. Oncotarget. 2018;9:25529-25544.
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  39. Lonial S, Lee HC, Badros A, et al. Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2): a two-arm, randomised, open-label, phase 2 study. Lancet Oncol. 2020;21:207-221.
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  41. Lonial S, Lee HC, Badros AZ, et al. DREAMM-2: single-agent belantamab mafodotin (belamaf) in patients with relapsed/refractory multiple myeloma (RRMM)—1-year outcomes by prior therapies. Program and abstracts of the 2020 ASH Annual Meeting and Exposition; December 5-8, 2020. Abstract 1417.
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  53. Van De Donk NWCJ, Popat R, Larsen J, et al. First results of iberdomide (IBER; CC-220) in combination with dexamethasone (DEX) and daratumumab (DARA) or bortezomib (BORT) in patients with relapsed/refractory multiple myeloma (RRMM). Program and abstracts of the 2020 ASH Annual Meeting and Exposition; December 5-8, 2020. Abstract 724.
  54. ClinicalTrials.gov. A study to determine dose, safety, tolerability and efficacy of CC-220 monotherapy, and in combination with other treatments in subjects with multiple myeloma. Available at: https://clinicaltrials.gov/ct2/show/NCT02773030. Accessed March 5, 2021.
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  57. ClinicalTrials.gov. A phase 1b-2, open-label study of JNJ-68284528, a chimeric antigen receptor T-cell (CAR-T) therapy directed against BCMA in subjects with relapsed or refractory multiple myeloma. Available at: https://clinicaltrials.gov/ct2/show/NCT03548207. Accessed March 5, 2021.
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  60. ClinicalTrials.gov. A phase 1 study of bb21217, an anti-BCMA CAR T cell drug product, in relapsed and/or refractory multiple myeloma. Available at: https://clinicaltrials.gov/ct2/show/NCT03274219. Accessed March 5, 2021.
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  62. ClinicalTrials.gov. Open-label, multicenter, phase 1 study to assess the safety of P BCMA-101 in subjects with relapsed/refractory multiple myeloma (MM) Followed by a Phase 2 Assessment of Response and Safety (PRIME). Available at: https://clinicaltrials.gov/ct2/show/NCT03288493. Accessed March 5, 2021.
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  64. ClinicalTrials.gov. A single-arm, open-label, phase 1 study of the safety, efficacy, and cellular kinetics/pharmacodynamics of ALLO-715 to evaluate an anti-BCMA allogeneic CAR T cell therapy with or without nirogacestat in subjects with relapsed/refractory multiple myeloma. available at: https://clinicaltrials.gov/ct2/show/nct04093596. accessed march 5, 2021.
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  66. ClinicalTrials.gov. A phase 1/2 open-label study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of AMG 701 monotherapy, or in combination with pomalidomide, with and without dexamethasone in subjects with relapsed or refractory multiple myeloma (ParadigMM-1B). Available at: https://clinicaltrials.gov/ct2/show/NCT03287908. Accessed March 5, 2021.
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  74. ClinicalTrials.gov. An open-label, multicenter, phase I trial evaluating the safety and pharmacokinetics of escalating doses of BFCR4350A in patients with relapsed or refractory multiple myeloma. Available at: https://clinicaltrials.gov/ct2/show/NCT03275103. Accessed March 5, 2021.
  75. Smith EL, Harrington K, Staehr M, et al. GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells. Sci Transl Med. 2019;11:(485):eaau7746.
  76. Chari A, Berdeja JG, Oriol A, et al. A phase 1, first-in-human study of talquetamab, a G protein-coupled receptor family C group 5 member D (GPRC5D) x CD3 bispecific antibody, in patients with relapsed and/or refractory multiple myeloma (RRMM). Program and abstracts of the 2020 ASH Annual Meeting; December 5-8, 2020. Abstract 290.
  77. ClinicalTrials.gov. A phase 1, first-in-human, open-label, dose escalation study of talquetamab, a humanized GPRC5D x CD3 bispecific antibody, in subjects with relapsed or refractory multiple myeloma. Available at: https://clinicaltrials.gov/ct2/show/NCT03399799. Accessed March 5, 2021.